Table 1. Thimerosal Content of Vaccines Routinely Recommended for Children 6 Years of Age and Younger - (updated 7/18/2005*)
*Since this update, a biologics license application was approved for Rotavirus Vaccine, Tradename-RotaTeq (Merck), that is thimerosal free and never contained thimerosal.
| | Thimerosal Status Concentration**(Mercury) | Approval Date for Thimerosal Free or Thimerosal / Preservative Free (Trace Thimerosal)*** Formulation |
| Infanrix
(GlaxoSmithKline Biologicals) | | Never contained more than a trace of thimerosal, approval date for thimerosal-free formulation 9/29/2000 |
Daptacel
(Sanofi Pasteur, Ltd) | | Never contained Thimerosal |
Tripedia
(Sanofi Pasteur, Inc) | Trace(≤0.3 µg Hg/0.5mL dose) | |
| Pediarix
(GlaxoSmithKline Biologicals) | | Never contained more than a Trace of Thimerosal, approval date for thimerosal-free formulation 1/29/2007 |
| Prevnar
(Wyeth Pharmaceuticals Inc) | | Never contained Thimerosal |
| IPOL
(Sanofi Pasteur, SA) | | Never contained Thimerosal |
| Varivax
(Merck & Co, Inc) | | Never contained Thimerosal |
Mumps, measles, and rubella | M-M-R-II
(Merck & Co, Inc) | | Never contained Thimerosal |
| Recombivax HB
(Merck & Co, Inc) | | |
Engerix B
(GlaxoSmithKline Biologicals) | | 03/28/00, approval date for thimerosal-free formulation 1/30/2007 |
Haemophilus influenzae type b conjugate (Hib) | ActHIB
(Sanofi Pasteur, SA)
OmniHIB
(GlaxoSmithKline) | | Never contained Thimerosal |
PedvaxHIB
(Merck & Co, Inc) | | |
HibTITER, single dose
(Wyeth Pharmaceuticals, Inc.)1 | | Never contained Thimerosal |
Hib/Hepatitis B combination | | | Never contained Thimerosal |
| Fluzone
(Sanofi Pasteur, Inc) | 0.01% (12.5 µg/0.25 mL dose, 25 µg/0.5 mL dose)2 | |
Fluzone
(Sanofi Pasteur, Inc)3
(no thimerosal) | | |
Fluvirin
(Novartis Vaccines and Diagnostics Ltd) | 0.01% (25 µg/0.5 mL dose) | |
Fluvirin
(Novartis Vaccines and Diagnostics Ltd)
(Preservative Free) | Trace (<1ug Hg/0.5mL dose) | |
| FluMist
(MedImmune Vaccines, Inc) | | Never contained Thimerosal |
** Thimerosal is approximately 50% mercury (Hg) by weight. A 0.01% solution (1 part per 10,000) of thimerosal contains 50 µg of Hg per 1 mL dose or 25 µg of Hg per 0.5 mL dose.
*** The term "trace" has been taken in this context to mean 1 microgram of mercury per dose or less.
1 HibTiITER was also manufactured in thimerosal-preservative containing multidose vials but these were no longer available after 2002.
2 Children 6 months old to less than 3 years of age receive a half-dose of vaccine, i.e., 0.25 mL; children 3 years of age and older receive 0.5 mL.
3 A trace thimerosal containing formulation of Fluzone was approved on 9/14/02 and has been replaced with the formulation without thimerosal.